Continuation Along Bifurcation Branches for a Tumor Model with a Necrotic Core

نویسندگان

  • Wenrui Hao
  • Jonathan D. Hauenstein
  • Bei Hu
  • Yuan Liu
  • Andrew J. Sommese
  • Yong-Tao Zhang
چکیده

We consider a free boundary problem for a system of partial differential equations, which arises in a model of tumor growth with a necrotic core. For any positive number R and 0 < ρ < R, there exists a radially-symmetric stationary solution with tumor free boundary r = R and necrotic free boundary r = ρ. The system depends on a positive parameter μ, which describes tumor aggressiveness, and for a sequence of values μ2 < μ3 < . . ., there exist branches of symmetrybreaking stationary solutions, which bifurcate from these values. Upon discretizing this model, we obtain a family of polynomial systems parameterized by μ. By continuously changing μ using a homotopy, we are able to compute nonradial symmetric solutions. We additionally discuss linear and nonlinear stability of such solutions.

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عنوان ژورنال:
  • J. Sci. Comput.

دوره 53  شماره 

صفحات  -

تاریخ انتشار 2012